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Semaglutide and tirzepatide belong to a class of medications called glucagon-like peptide-1 receptor agonists (GLP-1 RAs)

GLP-1 RA users also had a lower prevalence of chronic kidney disease, atrial fibrillation, and ischemic heart disease, but a higher prevalence of insulin use at baseline

The more recently published secondary-prevention arm of CANVAS demonstrated a more robust relative risk reduction among patients who had experienced a prior CV event

How retatrutide and Wegovy work Both medications work on the bodys appetite-regulating hormones, but they target different ones, which is why the trial results differ